A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria

Food Science and Human Wellness

Song Zhou¹  Xianxian Jia²  Zixuan Wang³  Chunling Ma³  Bin Cong⁴  Xiang Li⁴  Xiang Gao⁴  Yan Zhang⁴  Xiaoling Zhang⁵  Miaomiao Jia⁵  Dailun Hu⁶  Jun Zhang⁶  Shengqiang Du⁷ 

[1] Corresponding authors.;Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China;Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China;Department of Pathogen Biology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China;Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China;Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China;Shijiazhuang Great Wall Integrated Traditional Chinese and Western Medicine Hospital, Shijiazhuang 050035, China;

关键词: Probiotics;    Lactobacillus gasseri;    Antagonism;    Bacteria;    Safety evaluation;   

DOI  :  

来源: DOAJ

【 摘 要 】

To search for a new eco-friendly therapy for infectious disease caused by Escherichia coli, Staphylococcus aureus or Klebsiella oxytoca, we collected the vaginal swabs from healthy women, screened for Lactobacillus and found a strain repressing the growth of pathogenic bacteria. The new isolate was identified as L. gasseri by the colony morphology, Gram staining, biochemical reactions and confirmed by the 16S rDNA sequencing. The HMV18 strain inhibited the growth of food-borne pathogens such as E. coli, S. aureus and K. oxytoca. The HMV18 strain was sensitive to penicillin, ampicillin, erythromycin, tetracycline and chloramphenicol. The HMV18 strain produced α-hemolysis. Pathological histology of the mice ileum showed that the mucosa, villi, lamina propria and crypt depth remained intact and there was no inflammation or hyperemia in the L. gasseri HMV18 gavaged group. L. gasseri HMV18 could not up-regulate inflammatory cytokines level of plasma. All the results suggested L. gasseri HMV18 is a candidate probiotic to be an additive for food preservation or drug to prevent food-borne diseases.

【 授权许可】

Unknown