The Potent Phytoestrogen 8-Prenylnaringenin: A Friend or a Foe?

International Journal of Molecular Sciences

Atefeh Nasri¹  Raimo Pohjanvirta¹ 

[1] Department of Food Hygiene and Environmental Health, University of Helsinki, 00790 Helsinki, Finland;

关键词: phytoestrogens;    natural compounds;    xanthohumol;    isoxanthohumol;    naringenin;    flavonoids;   

DOI  :  10.3390/ijms23063168

来源: DOAJ

【 摘 要 】

8-prenylnaringenin (8-PN) is a prenylated flavonoid, occurring, in particular, in hop, but also in other plants. It has proven to be one of the most potent phytoestrogens in vitro known to date, and in the past 20 years, research has unveiled new effects triggered by it in biological systems. These findings have aroused the hopes, expectations, and enthusiasm of a “wonder-drug” for a host of human diseases. However, the majority of 8-PN effects require such high concentrations that they cannot be reached by normal dietary exposure, only pharmacologically; thus, adverse impacts may also emerge. Here, we provide a comprehensive and up-to-date review on this fascinating compound, with special reference to the range of beneficial and untoward health consequences that may ensue from exposure to it.

【 授权许可】

Unknown