The Protective Effect of Hamamelis virginiana Stem and Leaf Extract on Fine Dust-Induced Damage on Human Keratinocytes

Cosmetics

Dongki Yang¹  Joonseok Cha²  Jiyoung Choi²  Mi Yeon Moon²  Moon Sik Chang²  Gi Yeon Han² 

[1] Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Korea;Research Center, The Garden of Naturalsolution, Osan-si 18103, Korea;

关键词: particulate matter;    witch hazel;    keratinocyte;    inflammation;    skin barrier;   

DOI  :  10.3390/cosmetics8040119

来源: DOAJ

【 摘 要 】

Witch hazel extracts have been used for decades as cosmetic ingredients in skin care products. Our present study aims to evaluate its potential in anti-pollution products using a previously reported in vitro model. Calcium is a universal second messenger, and we used human respiratory and skin cells to detect changes in intracellular Ca²⁺ concentrations upon particulate matter contact. Both an increase in pro-inflammatory markers and a decrease in tight junction proteins were confirmed, as previously reported. Witch hazel stem and leaf extract showed significant attenuation of Ca²⁺ response upon the challenge; it displayed systematic regulations of the signal generator, PAR-2; a pro-inflammatory marker, NF-κB; and a tight junction protein, Occludin. We identified hexagalloylglucose from the extract and concluded that it is a major component regulating protection from particulate matter. Based on these results, witch hazel extract containing hexagalloylglucose is an active ingredient in anti-pollution skin care products.

【 授权许可】

Unknown