Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

Frontiers in Immunology

Marija Bedaj¹  Catherine Hughes²  Robert A Benson²  Pasquale Maffia³ 

[1] University of Birmingham;University of Glasgow;University of Naples Federico II;

关键词: Antigen Presentation;    Dendritic Cells;    Macrophages;    B cells;    antigen presenting cells;    Follicular dendritic cells;   

DOI  :  10.3389/fimmu.2016.00481

来源: DOAJ

【 摘 要 】

Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues, as well as identifying questions yet to be addressed.

【 授权许可】

Unknown