First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases

International Journal of Infectious Diseases

Anders Koch¹  Troels Lillebaek²  Tina Nørregaard Gissel³  Ulla Møller Weinreich⁴  Christian Wejse⁵  Camilla Hiul Suppli⁶  Anders Norman⁶  Dorte Bek Folkvardsen⁶ 

[1] Department of Clinical Medicine, Aalborg University, Aalborg, Denmark, Søndre Skovvej 15, DK-9000, Aalborg, Denmark;Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, Denmark;Department of Internal Medicine, Region Hospital Viborg, Denmark, Heibergs Alle 4F, DK-8800, Viborg, Denmark;Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark, Mølleparkvej 4, DK-9000, Aalborg, Denmark;Global Health Section, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, DK-1353, Copenhagen, Denmark;International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, Denmark;

关键词: Tuberculosis;    TB;    MDR-TB;    whole genome sequence WGS;    contact tracing;    Denmark;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Denmark is a low-incidence country for tuberculosis (TB) and multidrug-resistant (MDR) TB at 5 and 0.05 cases per 100,000 population, respectively. Until 2018, the transmission of MDR-TB was nonexistent except for a few pairwise related family cases. In this study, we describe the first MDR-TB outbreak in Denmark. Methods: On the basis of genotyping of all Mycobacterium tuberculosis (Mtb) culture-positive cases in Denmark spanning 3 decades, 6 molecular- and epidemiologically linked Danish-born cases were identified as the first cluster of an MDR-TB in Denmark. The primary case was diagnosed posthumously in 2010 followed by 5 epidemiologically linked cases from 2018 to 2019. Results and conclusion: Through a combination of routine Mtb genotyping and clinical epidemiological surveillance data, we identified the first Danish MDR-TB outbreak spanning 10 years and were able to disclose the specific transmission pathways in detail, which helped guide the outbreak investigations. The occurrence of an MDR-TB outbreak in a resource-rich low TB incidence setting such as Denmark highlights the importance of a collaborative control system combining classic contact tracing; timely identification of drug-resistant TB through rapid diagnostics; and a close collaboration between clinicians and classical- and molecular epidemiologists for the benefit of TB control.

【 授权许可】

Unknown