Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions

Applied Sciences

Mohamed Ould M’hamed¹  Abdulrahman G. Alshammari¹  O. M. Lemine² 

[1] Department of Chemistry, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia;Department of Physics, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia;

关键词: Biginelli reaction;    ball milling;    catalyst-free;    solvent-free;    dihydropyrimine derivatives;   

DOI  :  10.3390/app6120431

来源: DOAJ

【 摘 要 】

A simple, green, and efficient approach was used to synthesize 3,4-dihydropyrimidines derivatives. We showed that the application of the planetary ball milling method with a ball-to-reagent weight ratio of 8 for the Biginelli reaction provides 3,4-dihydropyrimidines derivatives with excellent yields (>98%) in a short reaction time from the one-pot, three-component condensation of aldehydes, ethyl acetoacetate, and urea (or thiourea).

【 授权许可】

Unknown