期刊论文详细信息
Applied Sciences | |
Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions | |
Mohamed Ould M’hamed1  Abdulrahman G. Alshammari1  O. M. Lemine2  | |
[1] Department of Chemistry, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia;Department of Physics, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia; | |
关键词: Biginelli reaction; ball milling; catalyst-free; solvent-free; dihydropyrimine derivatives; | |
DOI : 10.3390/app6120431 | |
来源: DOAJ |
【 摘 要 】
A simple, green, and efficient approach was used to synthesize 3,4-dihydropyrimidines derivatives. We showed that the application of the planetary ball milling method with a ball-to-reagent weight ratio of 8 for the Biginelli reaction provides 3,4-dihydropyrimidines derivatives with excellent yields (>98%) in a short reaction time from the one-pot, three-component condensation of aldehydes, ethyl acetoacetate, and urea (or thiourea).
【 授权许可】
Unknown