Shaping the learning curve: epigenetic dynamics in neural plasticity

Frontiers in Integrative Neuroscience

Zohar Ziv Bronfman¹  Eva eJablonka¹  Simona eGinsburg² 

[1] Tel Aviv University;The Open University of Israel;

关键词: DNA Methylation;    neural plasticity;    Non-coding RNA (ncRNA);    Learning Curve;    neuroepigenetics;   

DOI  :  10.3389/fnint.2014.00055

来源: DOAJ

【 摘 要 】

A key characteristic of learning and neural plasticity is state-dependent acquisition dynamics reflected by the non-linear learning curve that links increase in learning with practice. Here we propose that the manner by which epigenetic states of individual cells change during learning contributes to the shape of the neural and behavioral learning curve. We base our suggestion on recent studies showing that epigenetic mechanisms such as DNA methylation, histone acetylation and RNA-mediated gene regulation are intimately involved in the establishment and maintenance of long-term neural plasticity, reflecting specific learning-histories and influencing future learning. Our model, which is the first to suggest a dynamic molecular account of the shape of the learning curve, leads to several testable predictions regarding the link between epigenetic dynamics at the promoter, gene-network and neural-network levels. This perspective opens up new avenues for therapeutic interventions in neurological pathologies.

【 授权许可】

Unknown