Understanding the biological responses of nanostructured metals and surfaces

6th International Conference on Nanomaterials by Severe Plastic Deformation

材料科学;化学

Lowe, Terry C.^1 ; Reiss, Rebecca A.^2

Colorado School of Mines, George S. Ansell Department of Metallurgical and Materials Engineering, Golden CO 80401, United States^1

New Mexico Tech, Department of Biology, Socorro NM 87801, United States^2

关键词: Nanostructured biomaterials;    Nanostructured metals;    Nanostructured surface;    Next-generation dna sequencing;    Non-coding RNA (ncRNA);    Severe plastic deformations;    Theoretical foundations;    Ultra-fine grained ( UFG);   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/63/1/012172/pdf
DOI  :  10.1088/1757-899X/63/1/012172

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Metals produced by Severe Plastic Deformation (SPD) offer distinct advantages for medical applications such as orthopedic devices, in part because of their nanostructured surfaces. We examine the current theoretical foundations and state of knowledge for nanostructured biomaterials surface optimization within the contexts that apply to bulk nanostructured metals, differentiating how their microstructures impact osteogenesis, in particular, for Ultrafine Grained (UFG) titanium. Then we identify key gaps in the research to date, pointing out areas which merit additional focus within the scientific community. For example, we highlight the potential of next-generation DNA sequencing techniques (NGS) to reveal gene and non-coding RNA (ncRNA) expression changes induced by nanostructured metals. While our understanding of bio-nano interactions is in its infancy, nanostructured metals are already being marketed or developed for medical devices such as dental implants, spinal devices, and coronary stents. Our ability to characterize and optimize the biological response of cells to SPD metals will have synergistic effects on advances in materials, biological, and medical science.