The underexploited role of non-coding RNAs on lysosomal storage diseases

Frontiers in Endocrinology

Vânia D'Almeida¹  Cinthia Castro do Nascimento¹  Matheus Trovão De Queiroz¹  Vanessa Gonçalves Pereira¹ 

[1] Universidade Federal de São Paulo;

关键词: siRNA;    Lysosome;    MicroRNA (miRNA);    Non-coding RNA (ncRNA);    lysosomal storage disease;   

DOI  :  10.3389/fendo.2016.00133

来源: DOAJ

【 摘 要 】

Non-coding RNAs (ncRNA) are a functional class of RNA involved in the regulation of several cellular processes which may modulate disease onset, progression and prognosis. Lysosomal storage diseases (LSD) are a group of rare disorders caused by mutations of genes encoding specific hydrolases or nonenzimatic proteins, characterized by a wide spectrum of manifestations. The alteration of ncRNA levels is well established in several human diseases such as cancer and auto immune disorders; however, there is a lack of information focused on the role of ncRNA on rare diseases. Recent reports related to changes in ncRNA expression and its consequences on LSD physiopathology show us the importance to keep advancing on this field. This article will summarize recent findings and provide key points for further studies on LSD and ncRNA association.

【 授权许可】

Unknown