The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

Frontiers in Nutrition

Tongtong Bao¹  Lumin Gao¹  Liang Jiang²  Changming Ye²  Kai-Min Niu³  Xin Wu³  Meng Ru³  Shujin Wang⁴  Yumeng Li⁵ 

[1] CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences (CAS), Changsha, China;ERA Biotechnology (Shenzhen) Co., Ltd., Shenzhen, China;Institute of Biological Resources, Jiangxi Academy of Sciences, Nanchang, China;Institute of Life Sciences, Chongqing Medical University (CAS), Chongqing, China;Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China;

关键词: NMN;    telomere;    pre-aging;    microbiota;    metabolomic;   

DOI  :  10.3389/fnut.2021.756243

来源: DOAJ

【 摘 要 】

Aging is a natural process with concomitant changes in the gut microbiota and associate metabolomes. Beta-nicotinamide mononucleotide, an important NAD+ intermediate, has drawn increasing attention to retard the aging process. We probed the changes in the fecal microbiota and metabolomes of pre-aging male mice (C57BL/6, age: 16 months) following the oral short-term administration of nicotinamide mononucleotide (NMN). Considering the telomere length as a molecular gauge for aging, we measured this in the peripheral blood mononuclear cells (PBMC) of pre-aging mice and human volunteers (age: 45–60 years old). Notably, the NMN administration did not influence the body weight and feed intake significantly during the 40 days in pre-aging mice. Metabolomics suggested 266 upregulated and 58 downregulated serum metabolites. We identified 34 potential biomarkers linked with the nicotinamide, purine, and proline metabolism pathways. Nicotinamide mononucleotide significantly reduced the fecal bacterial diversity (p < 0.05) with the increased abundance of Helicobacter, Mucispirillum, and Faecalibacterium, and lowered Akkermansia abundance associated with nicotinamide metabolism. We propose that this reshaped microbiota considerably lowered the predicated functions of aging with improved immune and cofactors/vitamin metabolism. Most notably, the telomere length of PBMC was significantly elongated in the NMN-administered mice and humans. Taken together, these findings suggest that oral NMN supplementation in the pre-aging stage might be an effective strategy to retard aging. We recommend further studies to unravel the underlying molecular mechanisms and comprehensive clinical trials to validate the effects of NMN on aging.

【 授权许可】

Unknown