Pathophysiological relevance of mitochondria in NAD+ metabolism

FEBS Letters

Di Lisa, Fabio²  Ziegler, Mathias¹ 

[1] Institut für Biochemie, Freie Universität Berlin, Thielallee 63, 14195 Berlin, Germany;Dipartimento di Chimica Biologica, Università di Padova, Viale Giuseppe Colombo 3, I-35121 Padua, Italy

关键词: Permeability transition;    Myocardial ischemia;    Cell death;    Poly(ADP-ribose) polymerase;    ADP-ribosylation;    Cyclic ADP-ribose;    Oxyradical;    ART;    ADP-ribosyl transferase;    Δψ m;    mitochondrial membrane potential;    [Ca2+]i;    intracellular Ca2+;    cADPR;    cyclic ADP-ribose;    CsA;    cyclosporin A;    IMM;    inner mitochondrial membrane;    InsP 3;    inositol-1;    4;    5-trisphosphate;    NMN;    nicotinamide mononucleotide;    NMNAT;    nicotinamide mononucleotide adenylyltransferase;    PTP;    permeability transition pore;    NAADP;    nicotinic acid adenine dinucleotide phosphate;    PARP;    poly(ADP-ribose) polymerase;   

DOI  :  10.1016/S0014-5793(01)02198-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD⁺ metabolism and release that may contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events.

【 授权许可】

Unknown