Sodium yttrium fluoride based upconversion nano phosphors for biosensing

6th International Conference on Optical, Optoelectronic and Photonic Materials and Applications 2014

Nampi, Padmaja Parameswaran^1 ; Varma, Harikrishna^1 ; Biju, P.R.^2 ; Kakkar, Tarun^3 ; Jose, Gin^3 ; Saha, Sikha^4 ; Millner, Paul^5

Biomedical Technology Wing, Sree Chitra Tirunal Institute, Medical Sciences and Technology, Poojapura, Trivandrum-12, Kerala, India^1

School of Pure and Applied Physics, Mahatma Gandhi University, Kottayam, India^2

Institute for Materials Research, Houldsworth Building, University of Leeds, Clarendon Road, Leeds

LS2 9JT, United Kingdom^3

Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Clarendon Road, Leeds

LS2 9JT, United Kingdom^4

School of Biomedical Sciences, University of Leeds, Clarendon Road, Leeds

LS2 9JT, United Kingdom^5

关键词: Cardiac markers;    Chest pain;    Myocardial ischemia;    Nanophosphors;    Solution methods;    Synthesised;    Up-conversion;    Yttrium fluoride;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/619/1/012043/pdf
DOI  :  10.1088/1742-6596/619/1/012043

来源: IOP

【 摘 要 】

In the present study, NaYF4-Yb3+/Er3+having the composition NaYF4-18%Yb3+/2%Er3+and NaYF4-20%Yb3+/2%Er3+with and without the addition of PVP (polyvinyl pyrolidone) have been synthesised by a solution method using NaF, yttrium nitrate, ytterbium nitrate and erbium nitrate as precursors. Upconversion spectra of prepared nanomaterial under 980 nm laser excitation have been studied. The variation in upconversion spectra with new born calf serum and myoglobin has been studied. Myoglobin (Mb) may be helpful when used in conjunction with other cardiac markers for rapid determination of acute myocardial ischemia, especially in patients with a typical chest pain or nonspecific ECG changes. The variation of UC fluorescence with addition of Mb indicates the suitability of using NaYF4based UC nanoparticles in cardiac marker detection. The detailed study is currently under progress.