Biodegradable Magnesium Alloys Promote Angio‐Osteogenesis to Enhance Bone Repair

Advanced Science

Kang‐Sik Lee¹  Indong Jun²  James R. Edwards²  Sion Glyn‐Jones²  Hyun‐Kwang Seok³  Yu‐Chan Kim³  Kyungwoo Lee³  Hyung‐Seop Han³  Frank Witte⁴  Diego Mantovani⁵ 

[1] Biomedical Engineering Research Center, Asan Institute for Life Sciences Asan Medical Center, College of Medicine, University of Ulsan Seoul 05505 Republic of Korea;Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) University of Oxford Oxford OX3 7LD UK;Center for Biomaterials, Biomedical Research Institute Korea Institute of Science and Technology Seoul 02792 Republic of Korea;Department of Prostodontics, Geriatric Dentistry and Craniomandibular Disorders Charité‐Universitätsmedizin Berlin Berlin 14197 Germany;Laboratory for Biomaterials and Bioengineering, CRC‐I, Dept. Min‐Met‐Materials Engineering & CHU de Québec Research Center Laval University Quebec G1V 0A6 Canada;

关键词: angiogenesis;    biodegradable metals;    osteogenesis;   

DOI  :  10.1002/advs.202000800

来源: DOAJ

【 摘 要 】

Abstract Biodegradable metallic materials represent a potential step‐change technology that may revolutionize the treatment of broken bones. Implants made with biodegradable metals are significantly stronger than their polymer counterparts and fully biodegradable in vivo, removing the need for secondary surgery or long‐term complications. Here, it is shown how clinically approved Mg alloy promotes improved bone repair using an integrated state of the art fetal mouse metatarsal assay coupled with in vivo preclinical studies, second harmonic generation, secretome array analysis, perfusion bioreactor, and high‐resolution 3D confocal imaging of vasculature within skeletal tissue, to reveal a vascular‐mediated pro‐osteogenic mechanism controlling enhanced tissue regeneration. The optimized mechanical properties and corrosion rate of the Mg alloy lead to a controlled release of metallic Mg, Ca, and Zn ions at a rate that facilitates both angiogenesis and coupled osteogenesis for better bone healing, without causing adverse effects at the implantation site. The findings from this study support ongoing development and refinement of biodegradable metal systems to act as crucial portal technologies with significant potential to improve many clinical applications.

【 授权许可】

Unknown