Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering

Materials

Lutz-Christian Gerhardt¹ 

[1] Department of Materials, ImperialCollege London, Prince Consort Road, London SW7 2BP, UK

关键词: bioactive glasses;    glass-ceramics;    melt-derived glasses;    scaffolds;    bone;    tissue engineering;    composites;    ion release;    osteogenesis;    angiogenesis;   

DOI  :  10.3390/ma3073867

来源: mdpi

【 摘 要 】

Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.