Impact of readmissions on octogenarians with heart failure with preserved ejection fraction: PURSUIT‐HFpEF registry

ESC Heart Failure

Osaka CardioVascular Conference (OCVC)‐Heart Failure Investigators¹  Takaharu Hayashi²  Shinichiro Suna³  Daisaku Nakatani³  Yasushi Sakata³  Shungo Hikoso³  Yoshio Yasumura⁴  Akito Nakagawa⁴  Yusuke Nakagawa⁵  Takahisa Yamada⁶  Shunsuke Tamaki⁶  Kohei Ukita⁷  Yasuyuki Egami⁷  Naotaka Okamoto⁷  Yutaka Matsuhiro⁷  Hitoshi Nakamura⁷  Akihiro Tanaka⁷  Koji Yasumoto⁷  Masaki Tsuda⁷  Ryu Shutta⁷  Masami Nishino⁷  Yasuharu Matsunaga‐Lee⁷  Jun Tanouchi⁷  Akito Kawamura⁷  Masamichi Yano⁷ 

[1] ;Cardiovascular Division Osaka Police Hospital Osaka Japan;Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Suita Japan;Division of Cardiology Amagasaki Chuo Hospital Amagasaki Japan;Division of Cardiology Kawanishi City Hospital Kawanishi Japan;Division of Cardiology Osaka General Medical Center Osaka Japan;Division of Cardiology Osaka Rosai Hospital 1179‐3, Nagasonecho, Kita‐ku, Sakai Osaka 591‐8025 Japan;

关键词: Octogenarian;    Heart failure with preserved ejection fraction;    Diabetes mellitus;    N‐terminal pro‐B‐type natriuretic peptide;    Albumin;   

DOI  :  10.1002/ehf2.13293

来源: DOAJ

【 摘 要 】

Abstract Aims Heart failure (HF) readmissions with preserved ejection fraction (HFpEF) are increasing in the elderly, which is a major socioeconomic problem. We investigated the clinical impact of HF readmissions (HFR) on octogenarians with HFpEF. Methods and results We enrolled consecutive octogenarians (≥80 years old) from June 2016 to February 2020 in PURSUIT‐HFpEF registry. We divided them into HFR group readmitted for HF during the follow‐up period and non‐HF readmission (non‐HFR) group. We evaluated the impact of HFR on all‐cause mortality, cardiac death, and quality of life (QOL). Additionally, we evaluated the factors at discharge correlated with HFR. HFR group comprised 116 patients (21.4%). Among all‐cause deaths, 40 patients suffered cardiac deaths (48.2%). The Kaplan–Meier analysis revealed a similar prognosis between HFR and non‐HFR groups as well as similar incidences of HF deaths. The QOL scores had significantly deteriorated by 1 year later in the HFR group (0.71 ± 0.19 vs. 0.59 ± 0.21, P < 0.001), while it was similar at 1 year in the non‐HFR group. In the multivariate analysis, diabetes mellitus (DM) (P = 0.019), N‐terminal pro‐B‐type natriuretic peptide (NT‐pro BNP) levels ≥ 1611 pg/mL (P < 0.001), and serum albumin level ≤ 3.7 g/dL (P = 0.011) were useful markers for HFR in octogenarians. Conclusions In octogenarians with HFpEF, HF readmission was not directly correlated with the prognosis but was well correlated with the QOL. Close follow‐up is essential to decrease HFR of octogenarians with HFpEF with DM, high NT‐pro BNP (≥1611 pg/mL) and low albumin (≤3.7 g/dL) levels at discharge.

【 授权许可】

Unknown