Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

Brain Stimulation

Nicholas Ellens¹  Jessica F. Jordão¹  Tiffany Scarcelli²  Meaghan A. O'Reilly²  Isabelle Aubert³  Kullervo Hynynen⁴ 

[1] Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada;Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada;Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada;

关键词: Focused ultrasound;    Cell proliferation;    Neurogenesis;    Astrogenesis;    Hippocampus;   

DOI  :  

来源: DOAJ

【 摘 要 】

Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease.

【 授权许可】

Unknown