PRESAGE? as a new calibration method for high intensity focused ultrasound therapy

8th International Conference on 3D Radiation Dosimetry

Costa, M.^1,2 ; McErlean, C.^3 ; Rivens, I.^1 ; Adamovics, J.^4 ; Leach, M.O.^3 ; Haar, G Ter^1 ; Doran, S.J.^3,5

Department of Physics, Institute of Cancer Research, London, United Kingdom^1

Fundacao Para A Ciencia e A Tecnologia, Lisbon, Portugal^2

CRUK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom^3

Department of Chemistry and Biology, Rider University, Lawrenceville

NJ, United States^4

Department of Physics, University of Surrey, Guildford, United Kingdom^5

关键词: Energy depositions;    Exploratory studies;    Focused ultrasound;    High intensity focused ultrasound;    Optical computed tomography;    Reliable treatment planning;    Ultrasound exposure;    Ultrasound sources;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/573/1/012026/pdf
DOI  :  10.1088/1742-6596/573/1/012026

来源: IOP

【 摘 要 】

High Intensity Focused ultrasound (HIFU) is a non-invasive cancer therapy that makes use of the mainly thermal effects of ultrasound to destroy tissue. In order to achieve reliable treatment planning, it is necessary to characterise the ultrasound source (transducer) and to understand how the wave propagates in tissue and the energy deposition in the focal region. This novel exploratory study investigated how HIFU affects PRESAGE®, an optical phantom used for radiotherapy dosimetry, which is potentially a rapid method of calibrating the transducer. Samples, of two different formulations, were exposed to focused ultrasound and imaged using Optical Computed Tomography. First results showed that, PRESAGE® changes colour on ultrasound exposure (darker green regions were observed) with the alterations being related to the acoustic power and sample composition. Future work will involve quantification of these alterations and understanding how to relate them to the mechanisms of action of HIFU.