Dosimetric analysis of ultrasound-guided high intensity focused ultrasound ablation for breast fibroadenomas: a retrospective study

International Journal of Hyperthermia

卷:39

Lian Zhang¹  Cai Zhang¹  Tiansong Xia²  Mengdi Liang²  Zhibiao Wang³  Hongwei Yang⁴  Heng Yin⁴ 

[1] College of Biomedical Engineering, Chongqing Medical University, Chongqing, China;

[2] Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China;

[3] State Key Laboratory of Ultrasound Engineering in Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China;

[4] Suining Central Hospital, Suining, China;

关键词: High intensity focused ultrasound;    breast fibroadenoma;    energy efficiency factor;    dosage delivery;    acoustic pathway;   

DOI  :  10.1080/02656736.2022.2074151

来源: DOAJ

【 摘 要 】

Objective To investigate the factors influencing the sonication dosage and efficiency of ultrasound-guided high intensity focused ultrasound (USgHIFU) for breast fibroadenomas.Materials and Methods Forty-nine patients with 78 breast fibroadenomas who underwent USgHIFU were retrospectively analyzed. The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly influencing the sonication dosage, including age, body mass index (BMI), fibroadenoma size, distance from the shallow margin of the fibroadenoma to skin, distance from the deep margin of the fibroadenoma to pectoralis major, types of near field acoustic pathway, and Adler blood flow classification of ultrasound, were set as independent variables. The correlation between EEF and these independent variables were analyzed, and an optimal scaling regression model was established.Results Fibroadenoma size, distance from the shallow margin of the fibroadenoma to skin and type of near field acoustic pathway had significant correlation with EEF (p < 0.05). An EEF (ŷ) dosimetry model of ŷ= −0.496X1 + 0.287X2 + 0.203X3 was established, in which X1 stands for size of fibroadenoma, X2 stands for the distance from shallow margin of the fibroadenoma to skin, and X3 stands for type of near field acoustic pathway. The predicted EEF value was significantly related to actual EEF (R = 0.698, p = 0.000).Conclusions Fibroadenoma size, distance from the shallow margin of the fibroadenoma to skin and type of near field acoustic pathway could be used as predictors to evaluate the dosage delivery of USgHIFU treatment for breast fibroadenomas.

【 授权许可】

Unknown