Radiopharmaceutical Tracers for Neural Progenitor Cells

Mangner, Thomas J.

Wayne State University, Detroit, MI

关键词: Tomography Pet;    Neurogenesis;    Radiopharmaceuticals;    Animals;    62 Radiology And Nuclear Medicine;   

DOI  :  10.2172/892567
RP-ID  :  DOE/ER63607
RP-ID  :  FG02-03ER63607
RP-ID  :  892567

美国|英语

来源: UNT Digital Library

【 摘 要 】

The Technical Report summarizes the results of the synthesis and microPET animal scanning of several compounds labeled with positron-emitting isotopes in normal, neonatal and kainic acid treated (seizure induced) rats as potential PET tracers to image the process of neurogenesis using positron emission tomography (PET). The tracers tested were 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) and 5'-benzoyl-FTL, 1-(2'-deoxy-2'-[F-18]fluoro-B-D-arabinofuranosyl)-5-bromouracil (FBAU) and 3',5'-dibenzoyl-FBAU, N-[F-18]fluoroacetyl-D-glucosamine (FLAG) and tetraacetyl-FLAG, and L-[1-C-11]leucine.