Effects of neoadjuvant chemotherapy on the contralateral non-tumor-bearing breast assessed by diffuse optical tomography

Breast Cancer Research

Meghna S. Trivedi¹  Kevin Kalinsky¹  Katherine D. Crew¹  Dawn L. Hershman¹  Mariella Tejada¹  Melissa K. Accordino¹  Hanina Hibshoosh²  Hua Guo²  Mirella L. Altoe³  Andreas H. Hielscher³  Hyun K. Kim³  Alessandro Marone³ 

[1] Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center;Department of Pathology and Cell Biology, Columbia University Irving Medical Center;Departments of Biomedical Engineering, New York University Tandon School of Engineering;

关键词: Diffuse optical tomography;    Breast cancer;    Contralateral breast;    Menopausal status;    NAC;    pCR;   

DOI  :  10.1186/s13058-021-01396-w

来源: DOAJ

【 摘 要 】

Abstract Background The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR). Methods In this retrospective evaluation of 105 patients with stage II–III breast cancer, oxy-hemoglobin (ctO 2 Hb) from the contralateral non-tumor-bearing breast was collected and analyzed at different time points during NAC. The earliest monitoring imaging time point was after 2–3 weeks receiving taxane. Longitudinal data were analyzed using linear mixed-effects modeling to evaluate the contralateral breast ctO 2 Hb changes across chemotherapy when corrected for pCR status, age, and BMI. Results Patients who achieved pCR to NAC had an overall decrease of 3.88 μM for ctO 2 Hb (95% CI, 1.39 to 6.37 μM), p = .004, after 2–3 weeks. On the other hand, non-pCR subjects had a non-significant mean reduction of 0.14 μM (95% CI, − 1.30 to 1.58 μM), p > .05. Mixed-effect model results indicated a statistically significant negative relationship of ctO 2 Hb levels with BMI and age. Conclusions This study demonstrates that the contralateral normal breast tissue assessed by DOTBIS is modifiable after NAC, with changes associated with pCR after only 2–3 weeks of chemotherapy.

【 授权许可】

Unknown