Effects of neoadjuvant chemotherapy on the contralateral non-tumor-bearing breast assessed by diffuse optical tomography

Breast Cancer Research

Mariella Tejada¹  Melissa K. Accordino¹  Meghna S. Trivedi¹  Kevin Kalinsky¹  Dawn L. Hershman²  Katherine D. Crew²  Hanina Hibshoosh³  Hua Guo³  Andreas H. Hielscher⁴  Alessandro Marone⁴  Hyun K. Kim⁴  Mirella L. Altoe⁴ 

[1] Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, 10032,, New York, NY, USA;Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, 10032,, New York, NY, USA;Department of Epidemiology, Columbia University Irving Medical Center, 10032, New York, NY, USA;Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 10032, New York, NY, USA;Departments of Biomedical Engineering, New York University Tandon School of Engineering, 11201, Brooklyn, NY, USA;

关键词: Diffuse optical tomography;    Breast cancer;    Contralateral breast;    Menopausal status;    NAC;    pCR;   

DOI  :  10.1186/s13058-021-01396-w

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR).MethodsIn this retrospective evaluation of 105 patients with stage II–III breast cancer, oxy-hemoglobin (ctO2Hb) from the contralateral non-tumor-bearing breast was collected and analyzed at different time points during NAC. The earliest monitoring imaging time point was after 2–3 weeks receiving taxane. Longitudinal data were analyzed using linear mixed-effects modeling to evaluate the contralateral breast ctO2Hb changes across chemotherapy when corrected for pCR status, age, and BMI.ResultsPatients who achieved pCR to NAC had an overall decrease of 3.88 μM for ctO2Hb (95% CI, 1.39 to 6.37 μM), p = .004, after 2–3 weeks. On the other hand, non-pCR subjects had a non-significant mean reduction of 0.14 μM (95% CI, − 1.30 to 1.58 μM), p > .05. Mixed-effect model results indicated a statistically significant negative relationship of ctO2Hb levels with BMI and age.ConclusionsThis study demonstrates that the contralateral normal breast tissue assessed by DOTBIS is modifiable after NAC, with changes associated with pCR after only 2–3 weeks of chemotherapy.

【 授权许可】

CC BY