The Association and Mediating Biomarkers of Serum Retinol in Influencing the Development of Type 2 Diabetes: A Prospective Cohort Study in Middle-Aged and Elderly Population

Frontiers in Nutrition

Hongyin Li¹  Chunbo Wei¹  Ying Li¹  Changhao Sun¹  Xiaoyu Guo¹  Yingfeng Zhang¹  Yu Wang¹  Sen Yang¹  Xiuyu Pang² 

[1] Department of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, China;Department of Nutrition and Food Hygiene, School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, China;

关键词: type 2 diabetes;    nutrition epidemiology;    prevention;    cohort;    serum retinol;   

DOI  :  10.3389/fnut.2022.831950

来源: DOAJ

【 摘 要 】

The aims of this research are to elucidate whether serum retinol is associated with type 2 diabetes and to explore the underlying mechanisms of the association in a prospective cohort study. A total of 3,526 diabetes-free participants aged 40 years or older were enrolled at baseline in 2010–2012. Multivariable logistic regression was adopted to evaluate the associations of serum retinol and dietary vitamin A (VA) intake with type 2 diabetes. Mediation analyses were used to reveal potential mediators in their associations. After a mean follow-up of 5.3 years, 280 incident cases of type 2 diabetes occurred. Serum retinol was positively associated with the incidence of type 2 diabetes. The multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for type 2 diabetes from the bottom to the top quintile of serum retinol were 1, 1.878 (1.202, 2.936), 2.110 (1.364, 3.263), 1.614 (1.027, 2.538), and 2.134 (1.377, 3.306) (p-trend = 0.009), respectively. Mediation analysis showed that increased homeostasis model assessment - insulin resistance HOMA-IR, triglycerides (TG), and serum xanthine oxidase (XO) activity could account for 8.5, 14.7, and 12.1% of the total effects of serum retinol on type 2 diabetes, respectively. Serum retinol concentration was not significantly associated with dietary VA intake (r = −0.010, p = 0.570). In addition, no significant relationship was observed between dietary VA intake and the risk of type 2 diabetes. Overall, elevated serum retinol might increase the risk of type 2 diabetes which is mainly mediated by increased insulin resistance, TG, or serum XO activity.

【 授权许可】

Unknown