Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis

BMC Medicine

Frank B Hu¹  Walter C Willett¹  JoAnn E Manson³  Dariush Mozaffarian²  Edward Giovannucci¹  Qi Sun¹  Mu Chen⁴ 

[1] Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Division of Cardiovascular Medicine, and Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

关键词: meta-analysis;    cohort;    type 2 diabetes;    dairy;   

Others  :  1118165
DOI  :  10.1186/s12916-014-0215-1

 received in 2014-08-13, accepted in 2014-10-15,  发布年份 2014

【 摘 要 】

Background

The relation between consumption of different types of dairy and risk of type 2 diabetes (T2D) remains uncertain. Therefore, we aimed to evaluate the association between total dairy and individual types of dairy consumptions and incident T2D in US adults.

Methods

We followed 41,436 men in the Health Professionals Follow-Up Study (1986 to 2010), 67,138 women in the Nurses’ Health Study (1980 to 2010), and 85,884 women in the Nurses’ Health Study II (1991 to 2009). Diet was assessed by validated food-frequency questionnaires, and data were updated every four years. Incident T2D was confirmed by a validated supplementary questionnaire.

Results

During 3,984,203 person-years of follow-up, we documented 15,156 incident T2D cases. After adjustment for age, body mass index (BMI) and other lifestyle and dietary risk factors, total dairy consumption was not associated with T2D risk and the pooled hazard ratio (HR) (95% confidence interval (CI)) of T2D for one serving/day increase in total dairy was 0.99 (0.98, 1.01). Among different types of dairy products, neither low-fat nor high-fat dairy intake was appreciably associated with risk of T2D. However, yogurt intake was consistently and inversely associated with T2D risk across the three cohorts with the pooled HR of 0.83 (0.75, 0.92) for one serving/day increment (P for trend <0.001). We conducted a meta-analysis of 14 prospective cohorts with 459,790 participants and 35,863 incident T2D cases; the pooled relative risks (RRs) (95% CIs) were 0.98 (0.96, 1.01) and 0.82 (0.70, 0.96) for one serving total dairy/day and one serving yogurt/day, respectively.

Conclusions

Higher intake of yogurt is associated with a reduced risk of T2D, whereas other dairy foods and consumption of total dairy are not appreciably associated with incidence of T2D.

【 授权许可】

   
2014 Chen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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【 参考文献 】

• [1]Whiting DR, Guariguata L, Weil C, Shaw J: IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011, 94:311-321.
• [2]Economic costs of diabetes in the U.S. in 2012 Diabetes Care 2013, 36:1033-1046.
• [3]Rice BH, Cifelli CJ, Pikosky MA, Miller GD: Dairy components and risk factors for cardiometabolic syndrome: recent evidence and opportunities for future research. Adv Nutr 2011, 2:396-407.
• [4]Jakubowicz D, Froy O: Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and Type 2 diabetes. J Nutr Biochem 2013, 24:1-5.
• [5]Elwood PC, Pickering JE, Givens DI, Gallacher JE: The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: an overview of the evidence. Lipids 2010, 45:925-939.
• [6]Diet, nutrition and the prevention of chronic diseases.World Health Organ Tech Rep Ser 2003, 916:1–149. Backcover.
• [7]Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS: Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann Intern Med 2010, 153:790-799.
• [8]Aune D, Norat T, Romundstad P, Vatten LJ: Dairy products and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies. Am J Clin Nutr 2013, 98:1066-1083.
• [9]Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, Lyle BJ, Martini MC, Ursell LK, Clemente JC, Van Treuren W, Walters WA, Knight R, Newgard CB, Heath AC, Gordon JI: Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013, 341:1241214.
• [10]Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB: Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med 2011, 364:2392-2404.
• [11]Choi HK, Willett WC, Stampfer MJ, Rimm E, Hu FB: Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Intern Med 2005, 165:997-1003.
• [12]Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB: Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006, 29:650-656.
• [13]Malik VS, Sun Q, van Dam RM, Rimm EB, Willett WC, Rosner B, Hu FB: Adolescent dairy product consumption and risk of type 2 diabetes in middle-aged women. Am J Clin Nutr 2011, 94:854-861.
• [14]Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D, Willett WC: Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol 1999, 149:531-540.
• [15]Watt BK, Merrill AL: Composition of Foods: Raw, Processed, Prepared, Rev. Dec. 1963. Consumer and Food Economics Research Division, Agricultural Research Service, U.S. Dept. of Agriculture: for sale by the Superintendent of Documents, Washington; 1964.
• [16]Salvini S, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner B, Willett WC: Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol 1989, 18:858-867.
• [17]Feskanich D, Rimm EB, Giovannucci EL, Colditz GA, Stampfer MJ, Litin LB, Willett WC: Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. J Am Diet Assoc 1993, 93:790-796.
• [18]Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, Willett WC: Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 1992, 135:1114-1126. discussion 1127-1136
• [19]Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE: Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985, 122:51-65.
• [20]Hu FB, Rimm E, Smith-Warner SA, Feskanich D, Stampfer MJ, Ascherio A, Sampson L, Willett WC: Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr 1999, 69:243-249.
• [21]Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Data Group.Diabetes 1979, 28:1039–1057.
• [22]Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.Diabetes Care 1997, 20:1183–1197.
• [23]Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, Speizer FE: Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 1991, 338:774-778.
• [24]Hu FB, Leitzmann MF, Stampfer MJ, Colditz GA, Willett WC, Rimm EB: Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 2001, 161:1542-1548.
• [25]Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, Hennekens CH, Willett WC: Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 1997, 337:1491-1499.
• [26]Moher D, Liberati A, Tetzlaff J, Altman DG: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009, 339:b2535.
• [27]Gao D, Ning N, Wang C, Wang Y, Li Q, Meng Z, Liu Y: Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. PLoS One 2013, 8:e73965.
• [28][http://www.ncbi.nlm.gov/pubmed] webcite PubMed. []
• [29][http://www.embase.com/] webcite Embase. []
• [30]Zong G, Sun Q, Yu D, Zhu J, Sun L, Ye X, Li H, Jin Q, Zheng H, Hu FB, Lin X: Dairy consumption, type 2 diabetes, and changes in cardiometabolic traits: a prospective cohort study of middle-aged and older Chinese in Beijing and Shanghai. Diabetes Care 2014, 37:56-63.
• [31]Elwood PC, Pickering JE, Fehily AM: Milk and dairy consumption, diabetes and the metabolic syndrome: the Caerphilly prospective study. J Epidemiol Community Health 2007, 61:695-698.
• [32]Grantham NM, Magliano DJ, Hodge A, Jowett J, Meikle P, Shaw JE: The association between dairy food intake and the incidence of diabetes in Australia: the Australian Diabetes Obesity and Lifestyle Study (AusDiab). Public Health Nutr 2013, 16:339-345.
• [33]Kirii K, Mizoue T, Iso H, Takahashi Y, Kato M, Inoue M, Noda M, Tsugane S: Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort. Diabetologia 2009, 52:2542-2550.
• [34]Liu S, Choi HK, Ford E, Song Y, Klevak A, Buring JE, Manson JE: A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care 2006, 29:1579-1584.
• [35]Louie JC, Flood VM, Rangan AM, Burlutsky G, Gill TP, Gopinath B, Mitchell P: Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes. Nutr Metab Cardiovasc Dis 2013, 23:816-821.
• [36]Margolis KL, Wei F, de Boer IH, Howard BV, Liu S, Manson JE, Mossavar-Rahmani Y, Phillips LS, Shikany JM, Tinker LF: A diet high in low-fat dairy products lowers diabetes risk in postmenopausal women. J Nutr 2011, 141:1969-1974.
• [37]Sluijs I, Forouhi NG, Beulens JW, van der Schouw YT, Agnoli C, Arriola L, Balkau B, Barricarte A, Boeing H, Bueno-de-Mesquita HB, Clavel-Chapelon F, Crowe FL, de Lauzon-Guillain B, Drogan D, Franks PW, Gavrila D, Gonzalez C, Halkjaer J, Kaaks R, Moskal A, Nilsson P, Overvad K, Palli D, Panico S, Quirós JR, Ricceri F, Rinaldi S, Rolandsson O, Sacerdote C, Sánchez MJ, et al.: The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study. Am J Clin Nutr 2012, 96:382-390.
• [38]Soedamah-Muthu SS, Masset G, Verberne L, Geleijnse JM, Brunner EJ: Consumption of dairy products and associations with incident diabetes, CHD and mortality in the Whitehall II study. Br J Nutr 2013, 109:718-726.
• [39]Struijk EA, Heraclides A, Witte DR, Soedamah-Muthu SS, Geleijnse JM, Toft U, Lau CJ: Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. Nutr Metab Cardiovasc Dis 2013, 23:822-828.
• [40]van Dam RM, Hu FB, Rosenberg L, Krishnan S, Palmer JR: Dietary calcium and magnesium, major food sources, and risk of type 2 diabetes in U.S. black women. Diabetes Care 2006, 29:2238-2243.
• [41]Pereira MA, Jacobs DR Jr, Van Horn L, Slattery ML, Kartashov AI, Ludwig DS: Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA 2002, 287:2081-2089.
• [42]Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER 3rd, Simons-Morton DG, Karanja N, Lin PH: Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med 2001, 344:3-10.
• [43]Tremblay A, Gilbert JA: Milk products, insulin resistance syndrome and type 2 diabetes. J Am Coll Nutr 2009, 28:91S-102S.
• [44]Onakpoya IJ, Perry R, Zhang J, Ernst E: Efficacy of calcium supplementation for management of overweight and obesity: systematic review of randomized clinical trials. Nutr Rev 2011, 69:335-343.
• [45]Yanovski JA, Parikh SJ, Yanoff LB, Denkinger BI, Calis KA, Reynolds JC, Sebring NG, McHugh T: Effects of calcium supplementation on body weight and adiposity in overweight and obese adults: a randomized trial. Ann Intern Med 2009, 150:821-829. W145-826
• [46]van Meijl LE, Vrolix R, Mensink RP: Dairy product consumption and the metabolic syndrome. Nutr Res Rev 2008, 21:148-157.
• [47]Chen M, Pan A, Malik VS, Hu FB: Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2012, 96:735-747.
• [48]King JC: The milk debate. Arch Intern Med 2005, 165:975-976.
• [49]Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V: Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition 2012, 28:539-543.
• [50]Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V, Akbarian-Moghari A: Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci 2011, 94:3288-3294.
• [51]Parvez S, Malik KA, Ah Kang S, Kim HY: Probiotics and their fermented food products are beneficial for health. J Appl Microbiol 2006, 100:1171-1185.