Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis

BMC Medicine

Research Article

JoAnn E Manson¹  Qi Sun²  Mu Chen³  Edward Giovannucci⁴  Walter C Willett⁴  Frank B Hu⁴  Dariush Mozaffarian⁵ 

[1] Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Division of Cardiovascular Medicine, and Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;

关键词: dairy;    type 2 diabetes;    cohort;    meta-analysis;   

DOI  :  10.1186/s12916-014-0215-1

 received in 2014-08-13, accepted in 2014-10-15,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe relation between consumption of different types of dairy and risk of type 2 diabetes (T2D) remains uncertain. Therefore, we aimed to evaluate the association between total dairy and individual types of dairy consumptions and incident T2D in US adults.MethodsWe followed 41,436 men in the Health Professionals Follow-Up Study (1986 to 2010), 67,138 women in the Nurses’ Health Study (1980 to 2010), and 85,884 women in the Nurses’ Health Study II (1991 to 2009). Diet was assessed by validated food-frequency questionnaires, and data were updated every four years. Incident T2D was confirmed by a validated supplementary questionnaire.ResultsDuring 3,984,203 person-years of follow-up, we documented 15,156 incident T2D cases. After adjustment for age, body mass index (BMI) and other lifestyle and dietary risk factors, total dairy consumption was not associated with T2D risk and the pooled hazard ratio (HR) (95% confidence interval (CI)) of T2D for one serving/day increase in total dairy was 0.99 (0.98, 1.01). Among different types of dairy products, neither low-fat nor high-fat dairy intake was appreciably associated with risk of T2D. However, yogurt intake was consistently and inversely associated with T2D risk across the three cohorts with the pooled HR of 0.83 (0.75, 0.92) for one serving/day increment (P for trend <0.001). We conducted a meta-analysis of 14 prospective cohorts with 459,790 participants and 35,863 incident T2D cases; the pooled relative risks (RRs) (95% CIs) were 0.98 (0.96, 1.01) and 0.82 (0.70, 0.96) for one serving total dairy/day and one serving yogurt/day, respectively.ConclusionsHigher intake of yogurt is associated with a reduced risk of T2D, whereas other dairy foods and consumption of total dairy are not appreciably associated with incidence of T2D.

【 授权许可】

Unknown   
© Chen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.