The added value of chemical shift imaging in evaluation of bone marrow changes in sickle cell disease

The Egyptian Journal of Radiology and Nuclear Medicine

Manal Fayez Abu Samra¹  Mohammad Fouad Abdel-Baki Allam¹  Al Shaimaa Mahfouz Abdel Rahman¹ 

[1] Faculty of Medicine, Minia University;

关键词: In phase;    Out of phase;    Chemical shift imaging;    Bone marrow;    Sickle cell disease;   

DOI  :  10.1186/s43055-020-00384-y

来源: DOAJ

【 摘 要 】

Abstract Background The aim of this study was to assess the added value of chemical shift imaging when used with routine MRI study in evaluation of bone marrow changes in SCD. Forty-two patients with SCD and bone pain were included in the study; they underwent CSI and routine MRI study on the symptomatic anatomic part of the skeleton. Results Four patterns of diffuse bone marrow changes were recognized; they varied from persistent red marrow to diffuse hypointense patterns with abnormal signal loss percentage on CSI that suggest presence of iron overload (n = 28, 66.6%). Serum ferritin level was increasing in accordance to the degree of signal changes found on CSI with significant high negative correlation between the percentage of signal loss on CSI obtained from IP-OP/IP formula and serum ferritin level. In focal marrow lesions, all T1 hyperintense lesions demonstrated corresponding hyperintensity on IP and OP; the detection frequency on CSI was relatively higher on OP compared with IP images. Conclusion CSI has high diagnostic performance in detecting diffuse marrow changes and development of iron overload in SCD. In SCD-related focal marrow lesions, CSI could have a complementary role in detection of T1 hyperintensity and lesion conspicuity.

【 授权许可】

Unknown