Study of Tumour and Surrounding Tissue Heating with Near-Infrared Radiation after the Injection of Gold Nanoparticles into the Tissue

Journal of Biomedical Photonics & Engineering

Alla B. Bucharskaya¹  Valery V. Tuchin²  Marina L. Chekhonatskaya³  Daria K. Tuchina³  Georgy Terentyuk³  Alexey N. Bashkatov⁴  Elina A. Genina⁴  Nikolay G. Khlebtsov⁴  Vadim D. Genin⁴ 

[1] Tomsk State University, Russia;Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, Russia;Saratov State Medical University named after V.I. Razumovsky, Russia;Saratov State University, Russia;

关键词: tumour;    NIR laser irradiation;    photothermal therapy;    gold nanorods;   

DOI  :  10.18287/JBPE18.04.010505

来源: DOAJ

【 摘 要 】

We study the heating kinetics in transplanted model tumours after the intravenous injection of suspension of gold nanorods having the concentration from 400 to 1200 µg/mL under the laser irradiation at the wavelength 808 nm during 15 min. The object of study were 40 outbred white laboratory rats with transplanted liver cancer tumours (Cholangiocarcinoma PC1). The obtained results allow the optimisation of the gold nanorods injection technique at different degrees of vascularisation of tumour tissues aimed to provide the maximal heating of tumours by the laser radiation. It is shown that the maximal increase of the tumour temperature is related to the maximal accumulation of gold nanorods in the tumour tissues, observed in the case of its high vascularisation.

【 授权许可】

Unknown