DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice

Cancers

Alexander B. Kotlyar¹  Anastasia V. Ryabova²  Elena I. Shramova³  Marya V. Shilova³  Ivan V. Zelepukin³  Galina M. Proshkina³  Sergey M. Deyev³  Victoria O. Shipunova³ 

[1] Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences and the Center of Nanoscience and Nanotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel;Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St, 119991 Moscow, Russia;Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St, 16/10, 117997 Moscow, Russia;

关键词: cancer;    DARPin;    gold nanorods;    mice treatment;    near-infrared illumination;    photothermal therapy;   

DOI  :  10.3390/cancers13205235

来源: DOAJ

【 摘 要 】

Near-infrared phototherapy has great therapeutic potential for cancer treatment. However, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

【 授权许可】

Unknown