Choroidal thinning: Alzheimer's disease and aging

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Bruno Oliveira Santos¹  Diana Melancia²  Rita Almeida²  Helena Águas²  Arnaldo Dias‐Santos³  Rita Proença³  Joana Ferreira³  João Paulo Cunha³  Marta Alves⁴  Ana Luísa Papoila⁵  Carlota Louro⁵  António Castanheira‐Dinis⁶ 

[1] CEris‐ICIST, Instituto Superior Tecnico, Lisbon UniversityLisbonPortugal;Department of NeurologyCentral Lisbon Hospital CenterLisbonPortugal;Department of OphthalmologyCentral Lisbon Hospital CenterLisbonPortugal;Epidemiology and Statistics UnitResearch Centre, Central Lisbon Hospital CenterLisbonPortugal;NOVA Medical School, Universidade NOVA de LisboaLisbonPortugal;Visual Sciences Study CenterFaculty of MedicineLisbon UniversityLisbonPortugal;

关键词: Alzheimer's disease;    Aging;    Choroidal thickness;    Enhanced depth imaging;    Spectral‐domain optical coherence tomography;    Alzheimer's choroidopathy;   

DOI  :  10.1016/j.dadm.2017.03.004

来源: DOAJ

【 摘 要 】

Abstract Introduction The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients. Methods CT was measured manually in 13 locations at 500‐μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data. Results Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001—comparing with age‐match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea. Discussion Patients with AD showed a significant choroidal thinning even when compared with elderly subjects. The reduction of CT may aid in the diagnoses of AD, probably reflecting the importance of vascular factors in their pathogenesis.

【 授权许可】

Unknown