Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

Molecules

关键词: Dihydropyrimidines;    Biginelli reaction;    isomünchnones;    1;    3-dipolar cycloaddition reactions;    AM1 calculations;    conformation;   

DOI  :  10.3390/50300227

来源: DOAJ

【 摘 要 】

A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.

【 授权许可】

Unknown