Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin

Molecules

Meng-Ting Lin¹  He-Lin Xu¹  Ying-Zheng Zhao¹  Qing Yao¹  Yin-Di Zhu¹ 

[1] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China;

关键词: didymin;    dietary flavonoid glycoside;    therapeutic effects;    cancer;    neurodegenerative disorders;   

DOI  :  10.3390/molecules23102547

来源: DOAJ

【 摘 要 】

Didymin (isosakuranetin 7-O-rutinoside) is an orally bioactive dietary flavonoid glycoside first found in citrus fruits. Traditionally, this flavonoid has long been used in Asian countries as a dietary antioxidant. Recent studies have provided newer insights into this pleiotropic compound, which could regulate multiple biological activities of many important signaling molecules in health and disease. Emerging data also presented the potential therapeutic application of dietary flavonoid glycoside didymin against cancer, neurological diseases, liver diseases, cardiovascular diseases, and other diseases. In this review, we briefly introduce the source and extraction methods of didymin, and summarize its potential therapeutic application in the treatment of various diseases, with an emphasis on molecular targets and mechanism that contributes to the observed therapeutic effects. The dietary flavonoid didymin can be used to affect health and disease with multiple therapeutic targets, and it is anticipated that this review will stimulate the future development of this potential dietary medicine.

【 授权许可】

Unknown