Effects of Oral Diazepam on Visual Functions of Healthy Nigerian Volunteers

International Journal of Biomedical Research

Ibezim O. I.¹  Igwe S. A.²  Nwobodo N. N.³  Igwe J. I.⁴ 

[1]Department of Optometry, Abia State University, Uturu

[2]Department of Pharmacology and Therapeutics, College of Medicine, Enugu State University ofScience and Technology, Enugu

[3]Department of Pharmacology and Therapeutics, Ebonyi State University, Abakaliki,

[4]Department of Public Health, Enugu State University ofScience and Technology, Enugu

关键词: Diazepam;    sedative-hypnotic;    therapeutic effects;    visual functions;   

DOI  :  10.7439/ijbr.v6i6.2092

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Objectives: Diazepam, a benzodiazepine is used clinically for its anxiolytic, sedative-hypnotic, muscle-relaxant effects, and when used therapeutically, little or no attention is paid to its ocular effects or manifestations.Methods: The ocular manifestations or signs after therapeutic ingestion of diazepam on visual functions were determined in ten healthy young adult volunteers. The following visual functions were assessed: pupil size, amplitude of accommodation, near point of convergence, visual acuity at near and far, as well as distant and near phoria.Results: Revealed that diazepam has no effect on the pupil diameter, as well as near and distant visual acuity, while the near point of convergence and the amplitude of accommodation increased by 51% and 13.4% respectively. However, the phoria status tended towards orthophoria thereby enhancing existing heterophoria.Conclusion: Consequently, there is need for close monitoring to avoid negative effects on vision following prolonged use of diazepam.

【 授权许可】

CC BY