Assessment of antidepressant and sedative-hypnotic activities of methanolic crude extracts of Stephania japonica (Thunb.) Miers. whole plants

Current Issues in Pharmacy and Medical Sciences

Molla Md. Islam¹  Rahman Mahbubur¹  Rafe Md. Rajdoula¹  Dhar Ananta Sutra¹ 

[1] Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh;

关键词: antidepressant;    sedative-hypnotic;    forced swimming;    tail suspension;    open field;    hole-board;   

DOI  :  10.2478/cipms-2020-0010

来源: DOAJ

【 摘 要 】

In this study, methanolic crude extracts of Stephania japonica (Thunb.) Miers. (MESJ) whole plants were examined for possible antidepressant and sedative-hypnotic activities. Herein, the forced swimming test and tail suspension test were conducted to explore the antidepressant activity. In addition, the open field test and hole-board test were performed to evaluate the sedative-hypnotic activities. In the acute toxicity test, the MESJ ensured safety up to a dose of 2000 mg/kg, p.o. The experimental doses were 100 and 200 mg/kg p.o. In both the forced swimming test and tail suspension test, the extract significantly (p<0.01 and p<0.05) inhibited immobility time in a dose dependent manner compared to the control. These results (13.56-26.46% inhibition) indicate the mild antidepressant activity of MESJ compared to nortriptyline (60.4-64.6% inhibition). The open field test and hole-board test demonstrated the dose dependent significant (p<0.001, p<0.01 and p<0.05) and moderate sedative-hypnotic activities of the extract compared to diazepam. However, these activities were found to gradually decrease after 60 min in the open field test and must be considered as short-term activities, compared to diazepam. It can be claimed that the methanolic crude extract of Stephania japonica possesses mild antidepressant and moderate but short-term sedative-hypnotic activities.

【 授权许可】

Unknown