Functions and underlying mechanisms of miR-650 in human cancers

Cancer Cell International

Yuanshuai Su¹  Lingxiao Zhu¹  Lanjuan Li¹  Xinyu Gu¹  Juan Lu¹  Qiuxian Zheng¹ 

[1] State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang University;

关键词: MiR-650;    Cancer;    Expression;    Biological roles;    Oncogenesis;   

DOI  :  10.1186/s12935-022-02551-9

来源: DOAJ

【 摘 要 】

Abstract MicroRNAs (miRNAs) are one type of noncoding RNAs that interfere with mRNA translation to downregulate gene expression, which results in posttranscriptional gene silencing. Over the past two decades, miRNAs have been widely reported to impact the progression of malignant tumours by interfering with cancer initiation and progression; therefore, miRNAs represent potential new diagnostic and therapeutic tools. miR-650 is a newly identified miR, and increasing studies have demonstrated that miR-650 plays critical roles in cancer progression, such as mediating the Wnt signalling pathway/AXIN1 (axis inhibition protein 1) axis in hepatocellular carcinoma. Nevertheless, associations between the expression patterns and molecular mechanisms of miR-650 in cancer have not been comprehensively described. In this article, we review the existing evidence regarding the mechanisms by which miR-650 expression is altered and their relation to cancer. Moreover, the promising clinical application of miR-650 for diagnosis and treatment is highlighted.

【 授权许可】

Unknown