Relationship between DNA methylation and gene expression of the HOXB gene cluster in small cell lung cancers

FEBS Letters

Flagiello, Domenico¹  Poupon, Marie-France¹  Cillo, Clemente²  Malfoy, Bernard¹  Dutrillaux, Bernard¹ 

[1] Institut Curie, CNRS UMR 147, Section de Recherche, 26 rue d'Ulm, Paris, France;International Institute of Genetics and Biophysics, Naples, Italy

关键词: Methylation;    Expression;    Homeogene;    Cancer;    Lung;   

DOI  :  10.1016/0014-5793(96)00017-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression pattern of the HOXB gene cluster in four xenografted small-cell lung cancers was compared to the methylation of the DNA in the corresponding genomic regions. In 90% (17/19) of the studied cases, the expressed genes were in methylated regions whereas 70% (12/17) of the unexpressed genes were in unmethylated regions. This specific behavior could correspond to a particular gene expression regulation mechanism of the HOX gene network. Since some genes (HOXB2, HOXB4, HOXB7) were always inactive when unmethylated, this unexpected relationship might indicate their key function(s) in the HOX gene network.

【 授权许可】

Unknown