Nutraceutical oleuropein supplementation prevents high fat diet-induced adiposity in mice

Journal of Functional Foods

Hans J.M. Swarts¹  Evert M. van Schothorst²  Nikolaos Lemonakis³  Ioanna Andreadou³  Jaap Keijer⁴  Inge van der Stelt⁴  Elise F. Hoek-van den Hil⁴  Jacques J.M. Vervoort⁴  Leandros Skaltsounis⁴  Lisa Hoving⁵ 

[1] Toxicology, Wageningen University, Wageningen, The Netherlands;Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis, Athens, Greece;Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece;Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands;Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands;

关键词: Polyphenol;    Functional food ingredient;    Adiposity;    Obesity;    Energy balance;    Lipid metabolism;   

DOI  :  

来源: DOAJ

【 摘 要 】

Oleuropein, a phenolic compound present in olives and extra virgin olive oils, is endowed with in vivo beneficial health effects and might be considered a functional food ingredient. Here, we investigated the health effects of neutraceutical oleuropein supplementation (0.59% w/w) on energy balance at the whole body and molecular level in mice fed a high fat diet (HFD). Oleuropein supplementation (HFD + O) prevented HFD-induced body weight gain resulting in a body weight that was comparable to that of normal fat diet (NFD)-fed mice. Furthermore, indirect calorimetric data, motoric movements, serum glucose and leptin levels, serum and hepatic lipid levels, adipocyte size and adipose tissue gene expression showed an improved health status compared to the control HFD-fed mice. In fact, it appeared indistinguishable between HFD + O-fed mice and NFD-fed mice. Initially, oleuropein might decrease intestinal energy uptake, while on the longer term weight maintenance could be related to an increased satiety signal. Our results indicate that oleuropein supplementation to a HFD can improve health by reducing adiposity.

【 授权许可】

Unknown