Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee

Journal of Functional Foods

卷:1

Kentaro Kitadate¹  Maremi Sato-Ueshima²  Koji Wakame³  Hajime Fujii⁴  Jun Nishihira⁴ 

[1] Corresponding author: Address: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-4411, Hokkaido, Japan. Tel.: [phone];

[2] Knowledge Cluster, Sapporo Bio-S, Sapporo 001-0021, Hokkaido, Japan;

[3] fax: [phone].;

[4] Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu 069-4411, Hokkaido, Japan;

关键词: Adipokine;    Adiponectin;    Insulin resistance;    Metabolic syndrome;    Obesity;    Polyphenol;   

DOI  :  

来源: DOAJ

【 摘 要 】

The effect of low-molecular-weight polyphenols extracted from lychee (Oligonol) on metabolic syndrome characterized by abdominal obesity was examined. We performed a clinical trial for Oligonol conducted by randomized double-blind, placebo-controlled study. Eighteen (male, 14; female, 4) adult volunteers with abdominal circumference over 85 cm were enrolled and divided into two groups, Oligonol and placebo groups. All subjects took two capsules of Oligonol (50 mg/capsule) or placebo twice a day for 10 weeks. Physical and haematological examinations as well as a CT scan of the abdomen were carried out, before (control) and 10 weeks after Oligonol intake. Clinical parameters of body weight, abdominal circumference and visceral fat volume were significantly decreased in the Oligonol group compared to the control. Insulin resistance was improved by Oligonol in conjunction with elevation of serum adiponectin. These results suggest that Oligonol ameliorates metabolic syndrome by reducing visceral fat obesity.

【 授权许可】

Unknown