Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]

F1000Research

Andrea Gerbino¹  Matilde Colella¹  Aldebaran M. Hofer²  Silvana Curci² 

[1] Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari , Bari, Italy;Department of Surgery, Brigham & Women’s Hospital, Harvard Medical School and VA Boston Healthcare System, West Roxbury, MA, USA;

关键词: Cell Signaling;    Cell Signaling & Trafficking Structures;    Drug Discovery & Design;    Endocrine & Metabolic Pharmacology;    Membranes & Sorting;    Molecular Pharmacology;   

DOI  :  10.12688/f1000research.8963.1

来源: DOAJ

【 摘 要 】

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.

【 授权许可】

Unknown