Current status and future prospects for enabling chemistry technology in the drug discovery process [version 1; referees: 2 approved]

F1000Research

Stevan W. Djuric¹  Charles W. Hutchins¹  Nari N. Talaty¹ 

[1] Discovery Chemistry and Technology, AbbVie, North Chicago, IL, USA;

关键词: Biomacromolecule-Ligand Interactions;    Cell Signaling & Trafficking Structures;    Drug Discovery & Design;    Experimental Biophysical Methods;    Macromolecular Assemblies & Machines;    Membrane Proteins & Energy Transduction;    Pharmacokinetics & Drug Delivery;    Protein Folding;    Small Molecule Chemistry;    Theory & Simulation;   

DOI  :  10.12688/f1000research.9515.1

来源: DOAJ

【 摘 要 】

This review covers recent advances in the implementation of enabling chemistry technologies into the drug discovery process. Areas covered include parallel synthesis chemistry, high-throughput experimentation, automated synthesis and purification methods, flow chemistry methodology including photochemistry, electrochemistry, and the handling of “dangerous” reagents. Also featured are advances in the “computer-assisted drug design” area and the expanding application of novel mass spectrometry-based techniques to a wide range of drug discovery activities.

【 授权许可】

Unknown