MOCVD of Noble Metal Film Materials for Medical Implants: Microstructure and Biocompatibility of Ir and Au/Ir Coatings on TiNi

Coatings

EkaterinaS. Marchenko¹  AleksanderA. Zheravin²  ElenaV. Chepeleva²  YuriyA. Lantsukhay²  IlyaV. Korolkov³  TatyanaP. Koretskaya³  EugeneA. Maksimovskii³  AlphiyaR. Tsygankova³  NatalyaB. Morozova³  IgorP. Asanov³  EvgeniiaS. Vikulova³  KsenyaI. Karakovskaya³ 

[1] Laboratory for Medical Alloys and Shape Memory Implants, Tomsk State University, 36 Lenin Ave., 634050 Tomsk, Russia;Meshalkin National Medical Research Center, Ministry of Public Health of the Russian Federation, Rechkunovskaya Str. 15, 630055 Novosibirsk, Russia;Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave. 3, 630090 Novosibirsk, Russia;

关键词: MOCVD;    iridium;    gold;    titanium nickelide;    noble metal coatings;    medical implants;   

DOI  :  10.3390/coatings11060638

来源: DOAJ

【 摘 要 】

Noble metals such as Ir, Pt, Au are promising as coatings for metal medical implants to improve biocompatibility and corrosion resistance. Moreover, these coatings can be used as a basis for the further formation of bimetallic hetero-structures with enhanced antibacterial properties. In this work, we develop an approach to obtain such coatings by metal-organic chemical vapor deposition (MOCVD). We have been focused on the formation of Ir coating with developed morphology and subsequent discrete Au coating onto the titanium nickelide (TiNi) implant material. Iridium was deposited in an oxidizing atmosphere from the volatile precursor [Ir(cod)(acac)] (cod = cyclooctadiene-1,5, acac = acetylacetonate-anion). The effects of the deposition temperature (290–350 °C) and amount of introduced oxygen on the composition (Ir, Ir + IrO₂) and microstructure of the samples were studied. Hetero-metallic Au/Ir coatings were obtained using [(CH₃)₂Au(thd)] precursor (thd = dpm = dipivaloylmethanate-anion) at a deposition temperature of 240 °C in the presence of oxygen. To assess the biocompatibility, the toxicity of Ir/TiNi, Au/Ir/TiNi, and uncoated TiNi in relation to human embryonic stem cell line Man-1 was examined after 1, 3, and 5 days of incubation. The results obtained were explained based on the coating microstructures.

【 授权许可】

Unknown