期刊论文详细信息
Clinical Case Reports | |
Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy | |
Ellen Merete Hagen1  Michael P Lunn2  Istvan Bodi3  Gordon Thorpe Ingle4  | |
[1] Autonomic Unit National Hospital for Neurology and Neurosurgery London UK;Centre for Neuromuscular Disease National Hospital for Neurology and Neurosurgery London UK;Clinical Neuropathology King's College Hospital NHS Foundation Trust London UK;Neurology Department Whipps Cross University Hospital London UK; | |
关键词: autonomic dysfunction; Lewy body disease; multiple system atrophy; neurodegeneration; Parkinson's disease; α‐synuclein; | |
DOI : 10.1002/ccr3.3042 | |
来源: DOAJ |
【 摘 要 】
Abstract A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.
【 授权许可】
Unknown