Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy

Journal of Cellular and Molecular Medicine

Poul Henning Jensen¹  Hengjing Cui²  Lydia Zouzoula²  Susanna Norrbacka²  Samuli Auno²  Tommi Kilpeläinen²  Sampo Kurvonen²  Timo T. Myöhänen³  Kalevi Trontti⁴  Iiris Hovatta⁴ 

[1] Department of Biomedicine & DANDRITE, Aarhus University, Aarhus, Denmark;Division of Pharmacology and Pharmacotherapy/Drug Research Program, University of Helsinki, Helsinki, Finland;Division of Pharmacology and Pharmacotherapy/Drug Research Program, University of Helsinki, Helsinki, Finland;Integrative Physiology and Pharmacology Unit, Institute of Biomedicine, University of Turku, Turku, Finland;School of Pharmacy, University of Eastern Finland, Kuopio, Finland;SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland;Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland;Neuroscience Center, University of Helsinki, Helsinki, Finland;

关键词: alpha‐synuclein;    KYP‐2047;    multiple system atrophy;    neurodegeneration;    prolyl oligopeptidase;    synucleinopathies;   

DOI  :  10.1111/jcmm.16910

来源: Wiley

【 授权许可】

CC BY