Interactions between Calcium and Alpha-Synuclein in Neurodegeneration

Biomolecules

Alex Rcom-H𠆜heo-Gauthier¹  Jacob Goodwin¹ 

关键词: alpha-synuclein;    Parkinson’s disease;    calcium;    multiple system atrophy;    neurodegeneration;    oxidative stress;   

DOI  :  10.3390/biom4030795

来源: mdpi

【 摘 要 】

In Parkinson’s disease and some atypical Parkinson’s syndromes, aggregation of the α-synuclein protein (α-syn) has been linked to neurodegeneration. Many triggers for pathological α-syn aggregation have been identified, including port-translational modifications, oxidative stress and raised metal ions, such as Ca²⁺. Recently, it has been found using cell culture models that transient increases of intracellular Ca²⁺ induce cytoplasmic α-syn aggregates. Ca²⁺-dependent α-syn aggregation could be blocked by the Ca²⁺ buffering agent, BAPTA-AM, or by the Ca²⁺ channel blocker, Trimethadione. Furthermore, a greater proportion of cells positive for aggregates occurred when both raised Ca²⁺ and oxidative stress were combined, indicating that Ca²⁺ and oxidative stress cooperatively promote α-syn aggregation. Current on-going work using a unilateral mouse lesion model of Parkinson’s disease shows a greater proportion of calbindin-positive neurons survive the lesion, with intracellular α-syn aggregates almost exclusively occurring in calbindin-negative neurons. These and other recent findings are reviewed in the context of neurodegenerative pathologies and suggest an association between raised Ca²⁺, α-syn aggregation and neurotoxicity.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.