One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile

Molecules

MohamedA. A. Radwan¹  FahadM. Alminderej¹  HanemM. Awad² 

[1] Department of Chemistry, College of Science, Qassim University, Buraydah 51452, Saudi Arabia;Tanning Materials and Leather Technology Department, National Research Centre, El-Behouth St, Dokki, Cairo 12311, Egypt;

关键词: indole;    tetrazole;    pyrimidine;    multicomponent reaction (mcrs);    cytotoxicity;    hct-116;    mcf-7;    mda-mb-231;    a549;   

DOI  :  10.3390/molecules25020255

来源: DOAJ

【 摘 要 】

A series of novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile was synthesized via a one-pot, three-multicomponent reaction of appropriate aldehydes, 1H-tetrazole-5-amine and 3-cyanoacetyl indole in catalytic triethylamine. The cytotoxic activity of the new synthesized tetrazolopyrimidine-6-carbonitrile compounds was investigated against HCT-116, MCF-7, MDA-MB-231, A549 human cancer cell lines and one human healthy normal cell line (RPE-1) using the MTT cytotoxicity assay. Compounds 4h, 4b, 4c, 4i and 4a showed potent anticancer activities against human colon cancer. Additionally, all the compounds showed potent anticancer activities on human lung cancer.

【 授权许可】

Unknown