Synthesis of aminopyrimidylindoles structurally related to meridianins

TETRAHEDRON

卷:63

Article

Rossignol, Emilie¹  Youssef, Ali¹  Moreau, Pascale¹  Prudhomme, Michelle¹  Anizon, Fabrice¹ 

[1] Univ Blaise Pascal, SEESIB, UMR CNRS 6504, F-61377 Aubiere, France

关键词: meridianins;    kinase inhibitors;    pyrimidine;    indole;    antitumor agents;   

DOI  :  10.1016/j.tet.2007.07.095

来源: Elsevier

【 摘 要 】

The synthesis of new meridianin derivatives substituted at the C-5' position of the 2-aminopyrimidine ring by various aryl groups and substituted or not by a methyl group on the indole nitrogen is described. The 2-aminopyrimidine ring was obtained via a Bredereck synthesis. Aryl groups were introduced by Suzuki cross-coupling after bromination of the 2-aminopyrimidine ring at the C-5' position. (C) 2007 Elsevier Ltd. All rights reserved.

【 授权许可】

Free