Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives

Heterocyclic communications

article

Vidya S. Dofe¹  Aniket P. Sarkate²  Zarina M. Shaikh³  Charansingh H. Gill¹ 

[1] Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University;Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University;Department of Microbiology, Maulana Azad College of Arts, Science and Commerce

关键词: antimicrobial;    pyrazole;    pyrimidine;    tetrazole;    ultrasound;   

DOI  :  10.1515/hc-2017-0067

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

New tetrazole-based pyrazole and pyrimidine derivatives were synthesized by an ultrasound irradiation method. All compounds were characterized by infrared spectroscopy (IR), 1 H nuclear magnetic resonance (NMR), 13 C NMR, mass spectrometry (MS) and elemental analysis and assessed in vitro for their efficacy as antimicrobial agents against four bacteria ( Staphylococcus aureus , Bacillus subtilis , Escherichia coli , Pseudomonas aeruginosa ) and two fungi ( Candida albicans , Aspergillus niger ). Compounds 8a , 8e , 9a , 9b and 9e show potent activity against the tested strains compared to the reference drugs chloramphenicol and clotrimazole.

【 授权许可】

CC BY|CC BY-NC-ND