Anti-cancer peptide-based therapeutic strategies in solid tumors

Cellular & Molecular Biology Letters

Hamidreza Zalpoor¹  Zahra Payandeh²  Mohsen Nabi-Afjadi³  Mahdieh Khorsandi⁴  Armina Alagheband Bahrami⁵  Mohsen Karami Fath⁶  Azadeh Yaghoubian⁷  Maryam Zokaei⁸  Kimiya Babakhaniyan⁹  Asma Soofi^1,10  Sadaf Akbari^1,11  Fateme Jalalifar^1,12  Ali Azargoonjahromi^1,13 

[1] American Association of Kidney Patients;Department Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute;Department of Biochemistry, Faculty of biological science, Tarbiat Modares University;Department of Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences;Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences;Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University;Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University;Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology/National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences;Department of Medical Surgical Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences;Department of Physical Chemistry, School of Chemistry, College of Sciences, University of Tehran;Faculty of Pharmacy, Mashhad University of Medical Sciences;School of Medicine, Jiroft University of Medical Sciences;Shiraz University of Medical Sciences;

关键词: Peptide-based strategies;    Tumor-homing peptides;    Drug delivery;    Targeted delivery;   

DOI  :  10.1186/s11658-022-00332-w

来源: DOAJ

【 摘 要 】

Abstract Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively. Result Introducing beneficial therapeutic approaches, such as therapeutic peptides and their varied methods of action against tumor cells, can aid researchers in the discovery of novel peptides for cancer treatment. The biomedical applications of therapeutic peptides are highly interesting. These peptides, owing to their high selectivity, specificity, small dimensions, high biocompatibility, and easy modification, provide good opportunities for targeted drug delivery. In recent years, peptides have shown considerable promise as therapeutics or targeting ligands in cancer research and nanotechnology. Conclusion  This study reviews a variety of therapeutic peptides and targeting ligands in cancer therapy. Initially, three types of tumor-homing and cell-penetrating peptides (CPPs) are described, and then their applications in breast, glioma, colorectal, and melanoma cancer research are discussed.

【 授权许可】

Unknown