Block Copolymer Micelles in Drug Delivery and Cancer Therapy

Chronicles of Pharmaceutical Science

Narendra Lariya¹  Kuldeep Kumar Bansal*² 

[1] Vedica College of Pharmacy, R.K.D.F University, Bhopal, 462033 (M.P), India;Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Abo Akademi University, 20520 Turku, Finland

关键词: Micelles;    Targeted delivery;    Amphiphilic block copolymer;    Drug delivery;    Active targeting;    Passive targeting;   

DOI  :  

学科分类：医学（综合）

来源: Scientia Ricerca

【 摘 要 】

Block copolymer micelles has been emerged as a better and safer alternatives to small surfactant molecules for drug delivery applications. This review focused on the applications of amphiphilic blocks copolymer in drug delivery. The design of block copolymers along with the possible mechanism of drug loading in the hydrophobic core of the micelles has been presented. Further, fabrication methods of micelles were discussed along with shortcomings of individual procedure. The advantages of polymeric micelles in targeted cancer therapy have been stated giving emphasis on active and passive targeting. Finally, the prospective and improvement possibility in selection of block copolymers is being argued.

【 授权许可】

CC BY