The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population

Lipids in Health and Disease

Lin Yang¹  Yan Mao²  Qian Chen²  Yuanwei Liu³  Jiamin Wu³  Zichao Xiong³  Haiyue Li³  Guoqing Li³  Jianfeng Liu³  Yao Sun³  Yong Zhang⁴ 

[1] Department of Encephalopathy, Xi’an Hospital of Traditional Chinese Medicine;Department of Geriatrics, Xi’an Hospital of Traditional Chinese Medicine;Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University;The Second Department of Encephalopathy, Baoji Hospital of Traditional Chinese Medicine;

关键词: Population study;    Chinese;    Stroke;    CYP1A1;    CYP1A2;    Polymorphisms;   

DOI  :  10.1186/s12944-020-01370-z

来源: DOAJ

【 摘 要 】

Abstract Backgrounds Stroke is a sudden disorder of cerebral blood circulation. Many studies have illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke. This study aimed to observe the relationship between CYP1A1 and CYP1A2 variants and stroke risk in the Chinese population. Methods Agena MassARRAY Assay was used to genotype four single nucleotide polymorphisms (SNPs) in 477 cases and 480 controls. The chi-square test and logistic-regression analysis were used to explore the relationship between CYP1A1 and CYP1A2 variants and stroke risk. Results Individuals with CYP1A2 rs762551 C was associated with a lower risk of stroke than that of allele A. Age stratification analysis showed that rs762551 was only observed to be associated with a lower risk of stroke in ≤64ys age group. After gender stratification analysis, a significant association between rs762551 and stroke risk was found in males, but not in females. The four SNPs were found to be correlated with stroke risk in patients with hypertension, coronary heart disease, cerebral infarction and lacunar infarction. Conclusion In this study, the results first showed that CYP1A1 and CYP1A2 variants were associated with stroke risk. Larger and well-designed studies are needed to confirm the results.

【 授权许可】

Unknown