Potential of Curcumin in Skin Disorders

Nutrients

Mattia Falconi¹  Federico Iacovelli¹  Emi Dika²  Luca Bianchi³  Laura Vollono³  Elena Campione³  Roberta Gaziano⁴  Chiara Terracciano⁵ 

[1] Department of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 1–00133 Rome, Italy;Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Via Massarenti, 1–40138 Bologna, Italy;Dermatology Unit, Department of “Medicina dei Sistemi”, University of Rome Tor Vergata, Via Montpellier, 1–00133 Rome, Italy;Microbiology Section, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier, 1–00133 Rome, Italy;Neurology Unit, Guglielmo de Saliceto Hospital, 29121–29122 Piacenza, Italy;

关键词: curcumin;    antioxidants;    molecular docking;    inflammatory skin diseases;    psoriasis;    atopic dermatitis;    iatrogenic dermatitis;    wound care;    skin aging;    inflammaging;    skin cancer;    skin infections;   

DOI  :  10.3390/nu11092169

来源: DOAJ

【 摘 要 】

Curcumin is a compound isolated from turmeric, a plant known for its medicinal use. Recently, there is a growing interest in the medical community in identifying novel, low-cost, safe molecules that may be used in the treatment of inflammatory and neoplastic diseases. An increasing amount of evidence suggests that curcumin may represent an effective agent in the treatment of several skin conditions. We examined the most relevant in vitro and in vivo studies published to date regarding the use of curcumin in inflammatory, neoplastic, and infectious skin diseases, providing information on its bioavailability and safety profile. Moreover, we performed a computational analysis about curcumin’s interaction towards the major enzymatic targets identified in the literature. Our results suggest that curcumin may represent a low-cost, well-tolerated, effective agent in the treatment of skin diseases. However, bypass of limitations of its in vivo use (low oral bioavailability, metabolism) is essential in order to conduct larger clinical trials that could confirm these observations. The possible use of curcumin in combination with traditional drugs and the formulations of novel delivery systems represent a very promising field for future applicative research.

【 授权许可】

Unknown