Molecular Mediators of RNA Loading into Extracellular Vesicles

Cells

Chiara Corrado¹  Riccardo Alessandro¹  Chiara Zichittella¹  Alice Conigliaro¹  Maria Magdalena Barreca¹ 

[1] Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy;

关键词: exosomes;    extracellular vesicles;    non-coding RNA;    miRNAs;    lncRNAs;   

DOI  :  10.3390/cells10123355

来源: DOAJ

【 摘 要 】

In the last decade, an increasing number of studies have demonstrated that non-coding RNA (ncRNAs) cooperate in the gene regulatory networks with other biomolecules, including coding RNAs, DNAs and proteins. Among them, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are involved in transcriptional and translation regulation at different levels. Intriguingly, ncRNAs can be packed in vesicles, released in the extracellular space, and finally internalized by receiving cells, thus affecting gene expression also at distance. This review focuses on the mechanisms through which the ncRNAs can be selectively packaged into extracellular vesicles (EVs).

【 授权许可】

Unknown